FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion.

Robert J OldhamC Ian MockridgeSonya JamesPatrick J DuriezH T Claude ChanKerry L CoxVicentiu A PiticMartin J GlennieMark S Cragg

Published in: Journal for immunotherapy of cancer (2021)

This study highlights the importance of understanding the limitation of the mouse strain being used for preclinical evaluation, and demonstrates that NOD SCID strains of mice should be reconstituted with IgG prior to studies of mAb efficacy.

Keyphrases

high fat diet induced
cell therapy
escherichia coli
single cell
insulin resistance
stem cells
metabolic syndrome
innate immune
adipose tissue
bone marrow