4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Lujun XuJuan CaiChenrui LiMing YangTongyue DuanQing ZhaoYiyun XiLiya SunLiyu HeChengyuan TangLin SunPublished in: Molecular medicine (Cambridge, Mass.) (2023)
These data suggest that 4-OI ameliorates LPS-induced AKI by suppressing inflammation and oxidative stress and enhancing mitophagy through the overactivation of the Nrf2 signaling pathway, and inactivation of STAT3. Our study identifies 4-OI as a promising pharmacologic for S-AKI.
Keyphrases
- oxidative stress
- signaling pathway
- lps induced
- inflammatory response
- acute kidney injury
- induced apoptosis
- diabetic rats
- cell proliferation
- dna damage
- pi k akt
- ischemia reperfusion injury
- epithelial mesenchymal transition
- electronic health record
- genome wide
- gene expression
- dna methylation
- big data
- machine learning
- heat stress