Acute Thrombotic Events in Association With Coronavirus Disease of 2019 Immunization as Initial Presentation of Congenital Factor VII Deficiency.
Alyson TrilloJoanna A DavisKrysten SargentonFernando F Corrales-MedinaPublished in: Journal of pediatric hematology/oncology (2023)
Coagulation factor VII (FVII) deficiency is a congenital disorder with heterogeneous clinical phenotypes ranging from asymptomatic to life-threatening bleeding and/or thrombotic events. We present the case of an adolescent male who developed acute deep and superficial venous thromboses of the upper extremities in the setting of multiple peripheral venous line insertions and shortly after receiving his second coronavirus disease of 2019 immunization dose. A hemostatic work-up revealed low FVII activity levels associated with 4 different FVII genetic variants. We highlight the need to better understand the pathophysiologic mechanisms behind FVII deficiency-associated prothrombotic risk and the role that specific FVII genetic variants may play in the clinical presentation of these patients.
Keyphrases
- coronavirus disease
- liver failure
- end stage renal disease
- respiratory failure
- ejection fraction
- newly diagnosed
- chronic kidney disease
- replacement therapy
- young adults
- mental health
- drug induced
- prognostic factors
- aortic dissection
- peritoneal dialysis
- patient reported outcomes
- single cell
- hepatitis b virus
- intensive care unit
- mechanical ventilation
- extracorporeal membrane oxygenation
- soft tissue
- acute respiratory distress syndrome