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Coadministration of the prostaglandin F2α receptor antagonist preterm labour drug candidate OBE022 with magnesium sulfate, atosiban, nifedipine and betamethasone.

Oliver PohlLine MarchandJean-Pierre GottelandSimon CoatesJörg TäubelUlrike Lorch
Published in: British journal of clinical pharmacology (2019)
The use of OBE022, a PGF2α antagonist prodrug, in combination with standard-of-care medicines may provide new treatment alternatives for preterm labour. All tested combinations were well tolerated. Nifedipine doses could potentially be reduced or staggered when coadministered with OBE022.
Keyphrases
  • low birth weight
  • preterm birth
  • healthcare
  • gestational age
  • palliative care
  • preterm infants
  • quality improvement
  • cancer therapy
  • emergency department
  • drug delivery
  • smoking cessation