Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathy.
Andrew E RadbillLucy Y LeiSachin Y ParanjapeDaniel J BlackwellRobert L AbrahamDerek S ChewSatish R RajBjörn C KnollmannPublished in: PloS one (2021)
Rapid pacing trains triggered ventricular ectopy in hypertrophic cardiomyopathy patients, but not controls. This finding aligns with pre-clinical descriptions of excessive cardiomyocyte calcium loading during rapid pacing, increased post-pause sarcoplasmic reticulum calcium release, and subsequent calcium-triggered activity. Normal contractility at all diastolic intervals argues against clinical significance of altered length-dependent myofilament activation.
Keyphrases
- hypertrophic cardiomyopathy
- left ventricular
- cardiac resynchronization therapy
- heart failure
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- smooth muscle
- peritoneal dialysis
- weight gain
- prognostic factors
- physical activity
- high resolution
- atrial fibrillation
- high glucose
- clinical evaluation