Emerging role of mRNA epitranscriptomic regulation in chemoresistant cancer cells.

Published in: Molecular & cellular oncology (2020)

Cancer persister cells remain a significant barrier to effective anti-cancer therapy. We found that melanoma persister cells undergo a reversible reprogramming of mRNA translation. A subset of mRNAs, harboring N6-methyladenosine in their 5'-untranslated regions, is translationally up-regulated in an eIF4A-dependent manner. Targeting eIF4A prevents the emergence of resistant clones.

Keyphrases

cancer therapy
induced apoptosis
cell cycle arrest
drug delivery
endoplasmic reticulum stress
oxidative stress
signaling pathway
young adults
binding protein
mouse model