Diagnosis and treatment of anti-insulin antibody-mediated labile glycaemia in insulin-treated diabetes.

David S ChurchPeter BarkerKeith A BurlingShah K ShinwariCarmel KennedyDiarmuid SmithDavid P MacfarlaneAndrew KernohanAnna StearsMuhammad A KaramatKaren WhyteParth NarendranDavid J HalsallRobert K Semple

Published in: Diabetic medicine : a journal of the British Diabetic Association (2023)

Anti-insulin antibodies should be considered in insulin-treated diabetes with unexplained glycaemic lability. Combining immunoassays with PEG precipitation can stratify their significance. Antibody depletion may be beneficial, but conservative measures often suffice.

Keyphrases

type diabetes
glycemic control
cardiovascular disease
insulin resistance
drug delivery
weight loss
adipose tissue
metabolic syndrome