Accelarated immune ageing is associated with COVID-19 disease severity.

Janet M LordTonny VeenithJack SullivanArchana Sharma-OatesAlex G RichterNeil J GreeningHamish J C McAuleyRachael A EvansPaul MossShona C MooreLance TurtleNandan GautamAhmed GilaniManan BajajLouise V WainChristopher BrightlingBetty RamanMichael MarksAmisha SingapuriOmer ElneimaPeter J M OpenshawNiharika A Duggalnull nullnull null

Published in: Immunity & ageing : I & A (2024)

Our analyses reveal a state of enhanced immune ageing in survivors of severe COVID-19 and suggest this could be related to SARS-Cov-2 infection. Our data support the rationale for trials of anti-immune ageing interventions for improving clinical outcomes in these patients with severe disease.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
early onset
young adults
physical activity
clinical trial
electronic health record
genome wide
drug induced
dna methylation
gene expression