Genetic analysis of low-grade adenosquamous carcinoma of the breast progressing to high-grade metaplastic carcinoma.
Kae KawachiXiaoyan TangRika KasajimaTakashi YamanakaEigo ShimizuKotoe KatayamaRui YamaguchiKazuaki YokoyamaKiyoshi YamaguchiYoichi FurukawaSatoru MiyanoSeiya ImotoEmi YoshiokaKota WashimiYoichiro OkuboShinya SatoTomoyuki YokoseYohei MiyagiPublished in: Breast cancer research and treatment (2023)
Not only LGASC but also its associated high-grade MBC may be genetically different from de novo high-grade MBC. Progression from LGASC to high-grade MBC may involve the concentration of driver mutations caused by clonal selection and inactivation of tumor-suppressor genes.