Weight regain, but not weight loss exacerbates hepatic fibrosis during multiple weight cycling events in male mice.
Chun-Hsien ChiangTing-Rui ZhangPu-Sheng HsuShau-Ping LinChing-Yi ChenPublished in: European journal of nutrition (2024)
Weight cycling ending in weight gain exacerbated hepatic fibrosis, potentially by inducing apoptosis or disrupting mitochondrial homeostasis. Conversely, weight cycling ending in weight loss demonstrated beneficial effects on hepatic health.
Keyphrases
- weight loss
- weight gain
- bariatric surgery
- gastric bypass
- body mass index
- roux en y gastric bypass
- birth weight
- oxidative stress
- high intensity
- healthcare
- physical activity
- obese patients
- public health
- mental health
- cell death
- endoplasmic reticulum stress
- metabolic syndrome
- type diabetes
- adipose tissue
- cell cycle arrest
- insulin resistance
- cell proliferation
- risk assessment