Alpha-Synuclein RT-QuIC in Idiopathic Normal Pressure Hydrocephalus.
Alfonso FasanoIvan Martinez-ValbuenaPaula AzevedoCarolina Candeias da SilvaMusleh AlgarniAnna VasilevskayaChloe AnastassiadisFoad TaghdiriPaul KongkhamIvan RadovanovicGelareh ZadehAnthony E LangDavid F Tang-WaiGábor G KovácsMaria Carmela TartagliaPublished in: Annals of neurology (2022)
This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means of real-time quaking-induced conversion, a highly sensitive and specific technique capable of detecting and amplifying misfolded aggregated forms of α-synuclein in the cerebrospinal fluid. Seven patients were positive and they did not differ from negative cases, except for a more frequent L-dopa responsiveness and gait characterized by a wider base. The two groups did not differ in terms of response rate to tap test or shunt surgery, although step length and gait velocity improved by a lesser extent in positive cases. ANN NEUROL 2022;92:985-991.
Keyphrases
- cerebrospinal fluid
- end stage renal disease
- minimally invasive
- subarachnoid hemorrhage
- newly diagnosed
- ejection fraction
- chronic kidney disease
- risk assessment
- cerebral palsy
- coronary artery disease
- drug induced
- high resolution
- patient reported outcomes
- surgical site infection
- atrial fibrillation
- living cells
- neural network