Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia.

Yi NiuZiyou LinArabella WanLei SunShijia YanHeng LiangSiyue ZhanDongshi ChenXianzhang BuPeiqing LiuCeshi ChenWeiling HeXiongbin LuGuohui Wan

Published in: Hepatology (Baltimore, Md.) (2022)

Our work identifies ALDOA as an essential driver for HCC cell growth under hypoxia, and we demonstrate that inhibition of ALDOA in the hypoxic TME is a promising therapeutic strategy for treating HCC.

Keyphrases

genome wide
endothelial cells
dna methylation
copy number
gene expression