Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling.
Zaid H MaayahShingo TakaharaAbrar S AlamMourad FerdaoussiGopinath SutendraAyman O S El-KadiJohn R MackeyEdith PituskinD Ian PatersonJason R B DyckPublished in: BMC cancer (2020)
Overall, the findings of this study suggest that breast cancer cells play a greater role in inducing structural cardiac remodeling than previously appreciated and that tumor-derived endothelin-1 may play a pivotal role in this process.