Type 2 diabetes susceptibility genes on mouse chromosome 11 under high sucrose environment.
Misato KobayashiHironori UedaNaru BabayaMichiko Itoi-BabayaShinsuke NosoTomomi FujisawaFumihiko HorioHiroshi IkegamiPublished in: BMC genetics (2020)
Genes on mouse Chr 11 could explain glucose intolerance, impaired insulin secretion, insulin resistance in NSY mice under sucrose administration. Congenic mapping with high sucrose environment localized susceptibility genes for type 2 diabetes associated with impaired insulin secretion in the middle segment (26.0-63.4 Mb) of Chr 11. Gene(s) that decrease white adipose tissue were mapped to the distal segment of Chr 11. The identification of diabetogenic gene on Chr 11 in the future study will facilitate precision medicine in type 2 diabetes by controlling specific environments in targeted subjects with susceptible genotypes.
Keyphrases
- type diabetes
- genome wide identification
- genome wide
- bioinformatics analysis
- adipose tissue
- copy number
- glycemic control
- insulin resistance
- genome wide analysis
- transcription factor
- cardiovascular disease
- dna methylation
- high resolution
- blood glucose
- high fat diet induced
- high fat diet
- gene expression
- metabolic syndrome
- blood pressure
- weight loss