Effect of Saccharolactone on CYP-mediated metabolism of Xenobiotics.
Dayanidhi BeheraPankaj JainVishwanath KurawattimathNagaraj GowdaPublished in: Drug metabolism and bioanalysis letters (2023)
The findings indicated that saccharolactone being a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM), resulted in significant inhibition of the metabolism of compound-174, phenacetin and quinidine in HLM and caution should be exercised in using it with proper titration of the concentrations.
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