SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation.

Zivojin JevticVittoria MataforaFrancesca CasagrandeFabio SantoroSaverio MinucciMassimilliano Garre'Milad RasouliOlaf HeidenreichGiovanna MuscoJürg SchwallerAngela Bachi

Published in: Journal of experimental & clinical cancer research : CR (2022)

NUP98-NSD1 interacts and colocalizes on the genome with SMARCA5 which is an essential mediator of the NUP98-NSD1 transformation in hematopoietic cells. Formation of NUP98-NSD1 phase-separated nuclear condensates is not sufficient for the maintenance of transformed phenotype, which suggests that selective targeting of condensate constituents might represent a new therapeutic strategy for NUP98-NSD1 driven AML.

Keyphrases

induced apoptosis
cell cycle arrest
bone marrow
acute myeloid leukemia
endoplasmic reticulum stress
gene expression
signaling pathway
oxidative stress
cell proliferation
cell death
allogeneic hematopoietic stem cell transplantation
genome wide
cancer therapy