Countermeasure and therapeutic: A(1-7) to treat acute respiratory distress syndrome due to COVID-19 infection.
Maira SotoGere diZeregaKathleen Elizabeth RodgersPublished in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2020)
In the wake of the COVID-19 pandemic it has become clear that there is a need for therapies that are capable of reducing damage caused to patients from infections. Infections that induce Acute Respiratory Distress Syndrome (ARDS) are especially devastating because lung damage is so critical and difficult to manage. Angiotensin (1-7) [A(1-7)] has already been shown to protect pulmonary health and architecture in various models of disease. There is also evidence that A(1-7) can modulate immune function and protect various organs (lung, kidney, and heart) from oxidative damage and inflammation. Here we focus on making a case for the development of novel therapies that target the protective arm of the Renin Angiotensin System (RAS).
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- oxidative stress
- end stage renal disease
- healthcare
- ejection fraction
- newly diagnosed
- heart failure
- chronic kidney disease
- pulmonary hypertension
- mental health
- prognostic factors
- intensive care unit
- angiotensin ii
- atrial fibrillation
- patient reported outcomes
- peritoneal dialysis
- climate change
- patient reported