Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy.

Hannah ReimannAndrew NguyenJ Zachary SanbornCharles J VaskeStephen C BenzKayvan NiaziShahrooz RabizadehPatricia SpilmanAndreas MackensenMatthias RuebnerAlexander HeinMatthias W BeckmannEdith D van der MeijdenJudith BausenweinSascha KretschmannMarieke GriffioenJeffrey SchlomJames L GulleyKarin L LeeDuane H HamiltonPatrick Soon-ShiongPeter A FaschingAnita N Kremer

Published in: Journal for immunotherapy of cancer (2022)

We demonstrate our neoepitope prediction program allows for the successful identification of neoepitopes targeted by TILs in patients with BC, providing a means to identify tumor-specific immunogenic targets for individualized treatment, including vaccines or adoptively transferred cellular therapies.

Keyphrases

cancer therapy
drug delivery
bioinformatics analysis
quality improvement
combination therapy
transcription factor
human health
young adults