Generalized Acquired Cutis Laxa Associated with Monoclonal Gammopathy of Dermatological Significance.
Sophia Z ShalhoutMyrna R NahasReed E DrewsDavid Michael MillerPublished in: Case reports in dermatological medicine (2020)
The presence of monoclonal gammopathy is strongly associated with several dermatological entities such as acquired cutis laxa. We propose a new term for the dermatological manifestations caused by paraproteinemia: monoclonal gammopathy of dermatological significance, or MGODS, and stress the evaluation of an underlying gammopathy in the setting of certain dermatologic conditions, including scleromyxedema and amyloidosis. We present a case of a newly acquired cutis laxa secondary to plasma-cell dyscrasias that exemplifies MGODS, alongside a brief literature review, and underscore the clinical relevance of monoclonal gammopathies of dermatological significance.