RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance.

Timothy A McCaffreyIan TomaZhaoquing YangRichard KatzJonathan ReinerRamesh MazhariPalak ShahMichael TackettDan JonesTisha JepsonZachary FalkRichard WargodskyDmitry ShtakaloDenis AntonetsJustin ErtleJu H KimYinglei LaiZeynep ArslanEmily AledortMaha AlfaraidyGeorges St Laurent

Published in: BMC medical genomics (2021)

These studies identify a novel mRNA signature of a Treg-like defect in CAD patients and provides a blueprint for a diagnostic test for CAD. The pattern of changes is consistent with stress-related changes in the maturation of T and Treg cells, possibly due to changes in the immune synapse.

Keyphrases

coronary artery disease
end stage renal disease
induced apoptosis
ejection fraction
percutaneous coronary intervention
chronic kidney disease
cardiovascular events
prognostic factors
coronary artery bypass grafting
single cell
peritoneal dialysis
oxidative stress
endoplasmic reticulum stress
stress induced