Epstein-Barr virus infections are strongly dependent on activating and inhibitory KIR-HLA pairs after T-cell replate unrelated hematopoietic stem cell transplantation, the principles, and method of pairing analysis.
Jacek NowakSławomir GwozdowiczElżbieta Graczyk-PolRenata Mika-WitkowskaMarta Rogatko-KorosKlaudia NestorowiczUrszula SzlendakAgnieszka MalinowskaBeata KaczmarekBarbara Nasilowska-AdamskaMagdalena TormanowskaNatalia SzczurowskaJeremi SzypnickiAgnieszka WitkowskaMarta LasotaEwelina MalinowskaKazimierz HalaburdaPublished in: HLA (2020)
Viral infections are the main cause of increased morbidity and mortality among recipients in allogeneic hematopoietic stem cell transplantation (HSCT). Natural killer (NK) cells fight virally infected cells provided directional activation of cytotoxicity. In this study, we analyzed the role of receptor-ligand pairs that include inhibitory or activating killer cell immunoglobulin-like receptors (KIRs) with their HLA class I ligands in the course of viral infections. The paper also presents an algorithm that allows performing automated inhibitory (i) KIR:HLA pairing and rechecking in the clinical setting. The obtained results indicate a significant adverse roles of reduced number of iKIR:HLA pairs (40% vs 9%; odds ratio [OR] = 6.67; P = .0057; 95% confidence interval [CI] 1.74-25.62) and the presence of activating KIR:HLA pairs (15% vs 5%, OR = 3.58, P = .028, 95% CI 1.19-10.73) in EBV infections post HSCT.
Keyphrases
- epstein barr virus
- allogeneic hematopoietic stem cell transplantation
- nk cells
- signaling pathway
- diffuse large b cell lymphoma
- acute myeloid leukemia
- sars cov
- machine learning
- induced apoptosis
- deep learning
- acute lymphoblastic leukemia
- emergency department
- stem cells
- oxidative stress
- mesenchymal stem cells
- cell therapy
- cord blood
- cell death
- pi k akt