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EEG findings in CART T associated neurotoxicity: clinical and radiological correlations.

Isabelle BeuchatHusain DanishDaniel B RubinCaron JacobsonMatthew RobertsonHenrikas VaitkeviciusJong Woo Lee
Published in: Neuro-oncology (2021)
In adult patients experiencing neurotoxicity after CAR T cell infusion, EEG degree of background disorganization correlated with neurotoxicity severity. IIC patterns and focal EEG abnormalities are frequent and often correlate with focal clinical symptoms and with PET-hypometabolism/MRI-hypoperfusion, without structural lesion. The etiology of these findings remains to be elucidated.
Keyphrases
  • functional connectivity
  • resting state
  • working memory
  • computed tomography
  • contrast enhanced
  • magnetic resonance
  • positron emission tomography
  • cognitive impairment
  • high density
  • physical activity
  • pet imaging