Amine-Directed Palladium-Catalyzed C-H Halogenation of Phenylalanine Derivatives.

Alexia VilleJulien AnnibalettoSébastien Coufourier Christophe Hoarau Rodolphe Tamion Guillaume Journot Cédric Schneider Jean-François Brière

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2021)

Invited for the cover of this issue are Jean-François Brière, Cédric Schneider, Guillaume Journot and co-workers from the COBRA laboratory and Oril Industrie (Normandy, France). The image shows the progression from questioning how to easily and regioselectively introduce halogen atoms to amino acids to the discovery of a catalytic functional-group-directed C-H halogenation of phenylalanine derivatives. Read the full text of the article at 10.1002/chem.202102411.

Keyphrases

amino acid
structure activity relationship
small molecule
deep learning
high throughput
single molecule
smoking cessation
machine learning
crystal structure