Exploring the biotransformation of N-(2-hydroxyphenyl)-2-propylpentanamide (an aryl valproic acid derivative) by CYP2C11, using in silico predictions and in vitro studies.

Jessica Elena Mendieta-WejebeArianna Silva-TrujilloMartiniano BelloHumberto L Mendoza-FigueroaNorma Lizeth Galindo-AlvarezArnulfo AlboresFeliciano Tamay-CachMartha Cecilia Rosales-HernándezAurelio Romero-CastroCorrea-Basurto José

Published in: The Journal of pharmacy and pharmacology (2020)

Therefore, rat liver CYP2C11 isoform is able to metabolize HO-AAVPA.

Keyphrases

molecular docking
case control
oxidative stress
pi k akt
water soluble
signaling pathway