High Frequency of Prior SARS-CoV-2 Infection by Sensitive Nucleocapsid Assays.
Joseph P NkololaJinyan LiuAi-Ris Y CollierCatherine Jacob-DolanYasmeen SenussiElla BorbergZoe SwankDavid R WaltDan H BarouchPublished in: The Journal of infectious diseases (2024)
Prior infection with SARS-CoV-2 is typically measured by nucleocapsid serology assays. In this study, we show that the Simoa serology assays and T cell intracellular cytokine staining assays are more sensitive than the clinical Elecsys assay for detection of nucleocapsid-specific immune responses. These data suggest that the prevalence of prior SARS-CoV-2 infection in the population may be higher than currently appreciated.