The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study.
Binliang LiuTao AnMeiying LiZongbi YiChunxiao LiXiaoying SunXiuwen GuanLixi LiYanfeng WangYuhui ZhangBinghe XuFei MaYixin ZengPublished in: Cancer communications (London, England) (2018)
ECG abnormalities caused by chemotherapy are common in the real world. Autophagy-related SNPs are associated with chemotherapy-induced cardiotoxicity, thereby providing new evidence for autophagy as a cause of chemotherapy-induced cardiac damage.
Keyphrases
- chemotherapy induced
- early onset
- cell death
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- end stage renal disease
- late onset
- left ventricular
- ejection fraction
- locally advanced
- newly diagnosed
- rectal cancer
- peritoneal dialysis
- lymph node
- prognostic factors
- single molecule
- genome wide
- cell free
- heart rate
- heart rate variability
- circulating tumor
- patient reported outcomes
- copy number
- dna methylation
- circulating tumor cells