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Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study.

Michael WainbergAnubha MahajanAnshul KundajeMark I McCarthyErik IngelssonNicholas A Sinnott-ArmstrongManuel A Rivas
Published in: PLoS medicine (2019)
In a population-scale cohort, lower BMI was consistently associated with reduced diabetes risk across BMI, family history, and genetic risk categories, suggesting all individuals can substantially reduce their diabetes risk through weight loss. Our results support the broad deployment of weight loss interventions to individuals at all levels of diabetes risk.
Keyphrases
  • body mass index
  • weight loss
  • type diabetes
  • cardiovascular disease
  • glycemic control
  • weight gain
  • gene expression
  • dna methylation
  • skeletal muscle
  • copy number
  • gastric bypass
  • insulin resistance
  • breast cancer risk