Impact of single-nucleotide variants and nutritional status on population pharmacokinetics of Doxorubicin, and its effect on cardiotoxicity in children with leukemia.

Jesús Alonso Gándara-MirelesIsmael Lares-AsseffElio Aarón Reyes EspinozaIgnacio Villanueva FierroVerónica Loera CastañedaLourdes Patricia Cordova HurtadoCarla Díaz GonzálezLeslie Patrón RomeroHoracio Almanza Reyes

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2022)

Some covariates studied are directly related to the increase or decrease of the pharmacokinetic parameters of Doxorubicin. Decreased clearance, V2, and increased area under the curve were associated with systolic dysfunction, and decreased Q and V2 were associated with diastolic dysfunction. These results may contribute to the effective and safe use of Doxorubicin in pediatric patients with leukemia.

Keyphrases

drug delivery
left ventricular
blood pressure
cancer therapy
acute myeloid leukemia
bone marrow
oxidative stress
heart failure
young adults
copy number
gene expression
ejection fraction
dna methylation