Neoadjuvant Chemotherapy Followed by Vaginal Radical Trachelectomy as Fertility-Preserving Treatment for Patients with FIGO 2018 Stage 1B2 Cervical Cancer.
Petra L M ZusterzeelJohanna Wilhelmina Maria AartsFraukje J M PolPetronella B OttevangerMaaike A P C van HamPublished in: The oncologist (2020)
Standard treatment for women with International Federation of Gynecology and Obstetrics (FIGO) 2018 stage 1B2 cervical cancer (tumor size 2-4 cm) is a radical hysterectomy and pelvic lymph node dissection (PLND). However, many of these women are young and wish to preserve fertility. Data on fertility-sparing treatment options are sparse, but neoadjuvant chemotherapy followed by a vaginal radical trachelectomy and PLND could be an alternative. Since 2009 we performed an observational cohort study in which 18 women opted for this treatment in our center. In 14 women fertility could be preserved. In four patients the tumor recurred. In four women six pregnancies occurred. After careful selection this treatment could be a good fertility-sparing treatment option.
Keyphrases
- neoadjuvant chemotherapy
- polycystic ovary syndrome
- lymph node
- prostate cancer
- locally advanced
- type diabetes
- adipose tissue
- metabolic syndrome
- end stage renal disease
- rectal cancer
- pregnant women
- young adults
- robot assisted
- sentinel lymph node
- insulin resistance
- radical prostatectomy
- big data
- childhood cancer
- smoking cessation
- neural network