Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19.

Hannes VietzenAlexander ZoufalyMarianna TraugottJudith AberleStephan W AberleElisabeth Puchhammer-Stöckl

Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2021)

Our data show that these genetic variants in the NKG2C/HLA-E axis have a significant impact on the development of severe SARS-CoV-2 infections, and may help to identify patients at high-risk for severe COVID-19.

Keyphrases

sars cov
coronavirus disease
early onset
respiratory syndrome coronavirus
end stage renal disease
copy number
ejection fraction
newly diagnosed
drug induced
prognostic factors
natural killer cells
machine learning
big data
gene expression
binding protein
patient reported
genome wide identification