Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance.

Sha ZhangLiang YanCan CuiZhen WangJianhui WuAng LvMin ZhaoBin DongWenlong ZhangXiaoya GuanXiuyun TianChun-Yi Hao

Published in: OncoTargets and therapy (2020)

RRM2 was overexpressed in RLPS tissues, and downregulation of RRM2 could inhibit RLPS progression. In addition, suppression of RRM2 is expected to be a promising treatment for RLPS patients.

Keyphrases

cell proliferation
signaling pathway
end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
gene expression
prognostic factors
peritoneal dialysis
patient reported outcomes
robot assisted
replacement therapy