Colocalization of Wnt/β-catenin and ACTH signaling pathways and paracrine regulation in aldosterone producing adenoma.

Kelly De SousaAlaa B AbdellatifIsabelle Giscos-DouriezTchao MeatchiLaurence AmarFabio L Fernandes-RosaSheerazed BoulkrounMaria-Christina Zennaro

Published in: The Journal of clinical endocrinology and metabolism (2021)

Our results suggest that aldosterone producing structures in adrenals with APA share common molecular characteristics and cellular environment, despite different mutation status, suggesting common developmental mechanisms.

Keyphrases

cell proliferation
angiotensin ii
signaling pathway
epithelial mesenchymal transition
stem cells
high resolution
pi k akt
single molecule
induced apoptosis
endoplasmic reticulum stress