A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma.
Peter E HallRachel LewisNelofer SyedRichard ShafferJane EvansonStephen EllisMatthew WilliamsXiaoxing FengAmanda JohnstonJim A ThomsonFiona P HarrisRaj JenaTomasz MatysSarah JefferiesKate SmithBor-Wen WuJohn S BomalaskiTimothy CrookKevin O'NeillDimitris ParaskevopoulosRamsay S KhadeirMichael SheaffSimon PaceyPiers N PlowmanPeter W SzlosarekPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
In this recurrent HGG study, ADIPEMCIS was well tolerated and compares favorably to historical controls. Additional trials of ADI-PEG20 in HGG are planned.