N-Heterocyclic-Carbene-Catalyzed C-H Acylation via Radical Relay.

Published in: Organic letters (2022)

A method of N -fluorocarboxamide-directed N-heterocyclic-carbene (NHC)-catalyzed benzylic C-H acylation with aldehydes via the hydrogen atom transfer strategy is disclosed. This transformation involves a sequence of single-electron transfer, 1,5-hydrogen atom transfer, and radical cross-coupling steps. This method offers facile access to various highly functionalized ketones and exhibits good chemical yields and functional group tolerance.

Keyphrases

electron transfer
room temperature
visible light
quantum dots
highly efficient
molecular dynamics
mass spectrometry