Malachite green: a long-buried water-soluble AIEgen with near-infrared fluorescence for living cell nucleus staining.

Yuan LuoLihua ZhouLili DuYangzi XieXiang-Yang LouLintao CaiBen Zhong TangPing GongPengfei Zhang

Published in: Chemical communications (Cambridge, England) (2024)

Fluorescent imaging probes are crucial for exploring nucleus-related cellular events in live cells. Ideal probes should be photostable, small-sized, highly contrasted, and low in background. Here, we discovered that malachite green is a water-soluble near-infrared luminogen with aggregation-induced emission properties. Importantly, it can be used for living cell nucleus staining in a wash-free manner.

Keyphrases

water soluble
living cells
single cell
single molecule
small molecule
fluorescence imaging
induced apoptosis
high resolution
quantum dots
stem cells
cell cycle arrest
flow cytometry
cell proliferation
endoplasmic reticulum stress
drug induced
pi k akt