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Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia.

Hyojin ParkJessica FurtadoMathilde PouletMinhwan ChungSanguk YunSungwoon LeeWilliam C SessaClaudio A FrancoMartin A SchwartzAnne Eichmann
Published in: Circulation (2021)
Our study reveals ALK1 as an essential driver of flow-induced endothelial cell migration and identifies loss of flow-migration coupling as a driver of arteriovenous malformation formation in hereditary hemorrhagic telangiectasia disease. Integrin-YAP/TAZ signaling blockers are new potential targets to prevent vascular malformations in patients with hereditary hemorrhagic telangiectasia.
Keyphrases
  • high glucose
  • endothelial cells
  • room temperature
  • genome wide
  • dna methylation
  • gene expression
  • oxidative stress
  • drug induced
  • angiotensin converting enzyme
  • angiotensin ii
  • electron transfer
  • cell adhesion