Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.

Songwei FengBo DingZhu DaiHan YinYue DingSicong LiuKe ZhangHao LinZhongdang XiaoYang Shen

Published in: Journal of translational medicine (2024)

Neutralizing FGF7 in the medium or inhibiting HIF-1α signaling reversed the effects of FGF7-mediated EMT, emphasizing the dependence of FGF7-mediated EMT on HIF-1α activation. These findings suggest that targeting the FGF7/HIF-1α/EMT axis may offer new therapeutic opportunities to intervene in OC progression.

Keyphrases

epithelial mesenchymal transition
endothelial cells
signaling pathway
dna methylation
transcription factor
cancer therapy
dengue virus