Pharmacokinetics and pharmacodynamics of ropinirole in patients with prolactinomas.

Sihang LiuCan HuJane PetersAmanda TsangSerge CremersRobert BiesGabrielle Page-Wilson

Published in: British journal of clinical pharmacology (2018)

This data-rich study has informed our understanding of the clinical pharmacokinetics and pharmacodynamics of ropinirole, which are successfully captured by the proposed semi-mechanistic PKPD model. This model can be used to further investigate the PKPD of ropinirole and may facilitate the identification of optimal dose regimens for the treatment of prolactinomas and the establishment of a new therapeutic option for patients impacted by this rare disease.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
electronic health record
patient reported outcomes
big data
combination therapy
data analysis