Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults: A Prospective Cohort Study.

Zhen Zhou Joanne Ryan Andrew M Tonkin Sophia Zoungas Paul A Lacaze Rory Wolfe Suzanne G Orchard Anne M Murray John J McNeill Chenglong Yu Gerald F Watts Sultana Monira Hussain Lawrence J Beilin Michael E Ernst Nigel P Stocks Robyn L Woods Chao Zhu Christopher M Reid Raj C Shah Trevor T-J Chong Ajay Sood Kerry M Sheets Mark Raymond Nelson

Published in: Neurology (2023)

Older adults with higher triglyceride levels within the normal to high-normal range had a lower dementia risk and slower cognitive decline over time compared to individuals with lower triglyceride levels. Higher triglyceride levels may be reflective of better overall health and/or lifestyle behaviors that would protect against dementia development. Future studies are warranted to investigate whether specific components within the total circulating pool of plasma triglycerides may promote better cognitive function, with the hope of informing the development of new preventive strategies.

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