CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB.

Ya-Ling HsuMeng-Chi YenWei-An ChangPei-Hsun TsaiYi-Chung PanSsu-Hui LiaoPo-Lin Kuo

Published in: Breast cancer research : BCR (2019)

Our study reveals that MDSCs derived by CXCL17 contribute to the establishment of a lung metastatic niche by PDGF-BB secretion and provide a rationale for development of CXCL17 or PDGF-BB antagonists to inhibit or prevent lung metastasis in cases of breast cancer.

Keyphrases

growth factor
induced apoptosis
squamous cell carcinoma
small cell lung cancer
vascular smooth muscle cells
clinical trial
cell cycle arrest
cell death
endoplasmic reticulum stress
signaling pathway