Functional Analysis of the 3' Untranslated Region of the Human GRIN1 Gene in Regulating Gene Expression in vitro.

Yong-Ping LiuXue WuJing-Hua MengJun YaoBao-Jie Wang

Published in: Neuropsychiatric disease and treatment (2020)

miR-491-5p may bind to the 3'UTR of the GRIN1 gene (+799 bp - +805 bp, the next base of the stop codon is +1) and down-regulate gene expression in HEK-293, SK-N-SH, and U87 cell lines, which implicates a potential role of miR-491-5p in central nervous system diseases.

Keyphrases

gene expression
dna methylation
genome wide
copy number
endothelial cells
genome wide identification
transcription factor