Copper-Catalyzed Intramolecular Olefinic C(sp 2 )-H Amidation for the Synthesis of γ -Alkylidene- γ -lactams.

Herein, we report the copper-catalyzed dehydrogenative C(sp 2 )-N bond formation of 4-pentenamides via nitrogen-centered radicals. This reaction provides a straightforward and efficient preparation method for γ -alkylidene- γ -lactams. Notably, we could controllably synthesize α , β -unsaturated- or α , β -saturated- γ -alkylidene- γ -lactams depending on the reaction conditions.