Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in rats.
José Monteiro Sad PereiraAndré Luis BarreiraConrado Rodrigues GomesFelipe Mateus OrnellasDébora Santos OrnellasLuiz Carlos MirandaLucio Ronaldo CardosoRobson Coutinho-SilvaAlberto SchanaiderMarcelo M MoralesMaurilo LeiteChristina Maeda TakiyaPublished in: BMC nephrology (2020)
BBG, a known highly selective inhibitor of P2X7R, attenuated renal inflammation, collagen synthesis, renal cell apoptosis, and enhanced renal cell proliferation in the early phase of rat model of UUO.