Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice.

Hiromi KominatoKohei Takeda Koji MizutaniRisako MikamiDaisuke KidoPrima BuranasinNatsumi SaitoShu TakemuraKeita NakagawaToshiyuki NagasawaTakanori Iwata

Published in: Journal of periodontology (2021)

Metformin improved delayed gingival wound healing in insulin-resistant prediabetes by accelerating HGFs proliferation and migration via Akt phosphorylation in insulin signaling pathway.

Keyphrases

signaling pathway
wound healing
type diabetes
glycemic control
cell proliferation
pi k akt
protein kinase
epithelial mesenchymal transition
extracellular matrix
high fat diet induced
oxidative stress