Pathological investigation and viral antigen distribution of emerging African swine fever in Vietnam.
Uda Zahli IzzatiMinori InanagaNguyen Thi HoaPhawut NueangphuetOhnmar MyintQuang Lam TruongNguyen Thi LanJunzo NorimineTakuya HiraiRyoji YamaguchiPublished in: Transboundary and emerging diseases (2020)
African swine fever (ASF) is emerging in Vietnam and poses a continuing severe threat to the swine industry. A histopathological study of clinical samples collected during the May to July 2019 outbreak of ASF was performed to determine the characteristic lesions. We analysed samples from eight ASFV-infected farms. Histopathological results revealed the characteristic lesions of the acute to the subacute clinical form of ASF. Immunohistochemical results showed ASFV viral antigen distribution in mononuclear cells/macrophage in various organs, hepatocytes and renal tubular epithelium. Molecular analysis of partial capsid protein 72 gene revealed that ASFV strain from the eight separate outbreaks belonged to genotype II.
Keyphrases
- sars cov
- induced apoptosis
- single cell
- liver failure
- early onset
- cell cycle arrest
- genome wide
- gene expression
- peripheral blood
- dna methylation
- intensive care unit
- respiratory failure
- oxidative stress
- signaling pathway
- cell proliferation
- single molecule
- cell death
- small molecule
- extracorporeal membrane oxygenation
- protein protein
- binding protein
- endoplasmic reticulum stress
- acute respiratory distress syndrome
- mechanical ventilation