Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress.
Guang-Bing DuanJun-Wen WangHui-Hui SunZhi-Yu DongYan ZhangZhen-Xiang WangYe ChenYing ChenYing HuangShu-Chang XuPublished in: CNS neuroscience & therapeutics (2024)
Taken together, the results suggest that EphB2 in BLA plays an essential role in inducing visceral hypersensitivity. In the maintenance stage, the involvement of EphB2 is crucial but not sufficient. The increase in EphB2 induced by WAS may enhance synaptic plasticity in BLA through upregulating NMDARs, which results in IBS-like symptoms. These findings may give insight into the treatment of IBS and related psychological distress.
Keyphrases
- insulin resistance
- klebsiella pneumoniae
- irritable bowel syndrome
- chronic pain
- prefrontal cortex
- cell proliferation
- sleep quality
- functional connectivity
- neuropathic pain
- transcription factor
- stress induced
- escherichia coli
- drug induced
- type diabetes
- adipose tissue
- physical activity
- skeletal muscle
- depressive symptoms
- replacement therapy
- smoking cessation