An accelerated Rauhut-Currier dimerization enabled the synthesis of (±)-incarvilleatone and anticancer studies.
Tharun K KotammagariSweta MisraSayantan PaulSunita KunteRajesh G GonnadeManas Kumar SantraAsish K BhattacharyaPublished in: Beilstein journal of organic chemistry (2023)
The total synthesis of racemic incarvilleatone has been achieved by utilizing unexplored accelerated Rauhut-Currier (RC) dimerization. The other key steps of the synthesis are oxa-Michael and aldol reactions in a tandem sequence. Racemic incarvilleatone was separated by chiral HPLC and the configuration of each enantiomer was determined by single-crystal X-ray analysis. In addition, a one-pot synthesis of (±)-incarviditone has been achieved from rac -rengyolone by using KHMDS as a base. We have also assessed the anticancer activity of all the synthesized compounds in breast cancer cells nonetheless, they exhibited very limited growth suppression activity.
Keyphrases
- breast cancer cells
- high resolution
- simultaneous determination
- magnetic resonance imaging
- computed tomography
- escherichia coli
- acinetobacter baumannii
- cystic fibrosis
- ionic liquid
- pseudomonas aeruginosa
- high performance liquid chromatography
- dual energy
- case control
- klebsiella pneumoniae
- capillary electrophoresis
- solid phase extraction
- data analysis
- amino acid