Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT-Hook Adaptor.
Soraya Learte-AymamíJéssica RodríguezM Eugenio VázquezJosé Luis MascareñasPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
The nickel(II)-mediated self-assembly of a multimeric DNA binder is described. The binder is composed of two metal-chelating peptides derived from a bZIP transcription factor (brHis2 ) and one short AT-hook domain equipped with two bipyridine ligands (HkBpy2 ). These peptides reversibly assemble in the presence of NiII ions at selected DNA sequences of 13 base pairs.