The role of SIRT5 and p53 proteins in the sensitivity of colon cancer cells to chemotherapeutic agent 5-Fluorouracil.

Ozlem EkremogluAsli Koc

Published in: Molecular biology reports (2021)

In this study, the effect of 5-FU on SIRT5 and FOXO 3a proteins was determined for the first time in HCT-116 p53 +/+ and HCT-116 p53 -/- cells. These results may help the discovery of new markers in colon cancer treatment.

Keyphrases

cell cycle arrest
pi k akt
induced apoptosis
cell death
oxidative stress
signaling pathway
small molecule
transcription factor
high throughput
single cell