The tale of microencapsulated rifampicin: is it useful for the treatment of periprosthetic joint infection?
Irene Isabel López-TorresJavier Vaquero-MartínAna-Isabel Torres-SuárezFederico Navarro-GarcíaAna-Isabel Fraguas-SánchezVíctor Estuardo León-RománPablo Sanz-RuízPublished in: International orthopaedics (2022)
The in vivo analyses demonstrated the superiority of cement containing gentamicin and rifampicin microcapsules versus the isolated use of gentamicin in the treatment of PJI in the rabbit model without serious side effects due to the systemic absorption of rifampicin. Given the increasing incidence of staphylococci-related PJI, the development of new strategies for intra-articular administration of rifampicin for its treatment has a high clinical impact.